{"id":73077,"date":"2016-03-28T00:38:10","date_gmt":"2016-03-28T04:38:10","guid":{"rendered":"https:\/\/canadianinquirer.net\/v1\/?p=73077"},"modified":"2017-01-29T03:36:50","modified_gmt":"2017-01-29T08:36:50","slug":"key-hiv-treatment-found-human-blood","status":"publish","type":"post","link":"https:\/\/canadianinquirer.net\/v1\/2016\/03\/28\/key-hiv-treatment-found-human-blood\/","title":{"rendered":"Key to HIV treatment found in human blood"},"content":{"rendered":"
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MOSCOW, March 28\u2014A group of scientists from Scripps Research Institute (TSRI ) discovered that immune cells able to conquer HIV are present in the human body.<\/p>\n

Some people infected with HIV can produce antibodies that effectively neutralize many strains of the dangerous, rapidly mutating virus. A healthy person, however, would need to be immunized with special antigens in order to produce the required antibodies.<\/p>\n

The success of a potential vaccine depends on the ability of the immunogen to bind with cells called B-lymphocytes and to activate them so that they produce antibodies. A team of scientists wrote in a new study published in Science magazine on March 24 that most people have so-called “embryo” precursor cells in their bodies which can generate VRC01 antibodies needed to conquer HIV cells.<\/p>\n

The scientists tried to develop a special kind of immunogen which would bind certain B-lymphocytes, potentially responsible for immunity against HIV. The immunogen has to be very unique because the required progenitor cells are very rare among other B-lymphocytes.<\/p>\n

“We found that almost everybody has these broadly neutralizing antibody precursors, and that a precisely engineered protein can bind to these cells that have potential to develop into HIV broadly neutralizing antibody-producing cells, even in the presence of competition from other immune cells,” said the study’s lead author, TSRI professor William Schief.<\/p>\n

The immunologists synthesized protein immunogen EOD-GT8 60mer. The research showed that mice vaccinated with the protein generate VRC01 antibodies. If EOD-GT8 60mer can trigger the same reaction in humans, the scientists may then develop several more immunogens that will jointly cause the synthesis of a wide range of antibodies able to conquer HIV.<\/p>\n

In a recent article published in Scientific Reports magazine, genetic scientists wrote that CRISPR\/Cas9 technology is able to remove HIV virogenes from infected T-lymphocytes which the virus usually attacks. The finding may help to develop new methods of therapy for people with AIDS.<\/p>\n","protected":false},"excerpt":{"rendered":"

MOSCOW, March 28\u2014A group of scientists from Scripps Research Institute (TSRI ) discovered that immune cells able to conquer HIV …<\/p>\n","protected":false},"author":33,"featured_media":64077,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[9926,3075,9927,35],"class_list":["post-73077","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-blood","tag-hiv","tag-hiv-treatment","tag-original","mauthors-sputnik-international-via-philippines-news-agency"],"_links":{"self":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/73077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/comments?post=73077"}],"version-history":[{"count":0,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/73077\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media\/64077"}],"wp:attachment":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media?parent=73077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/categories?post=73077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/tags?post=73077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}