{"id":270727,"date":"2020-10-03T08:51:33","date_gmt":"2020-10-03T12:51:33","guid":{"rendered":"https:\/\/canadianinquirer.net\/v1\/?p=270727"},"modified":"2020-10-03T08:51:33","modified_gmt":"2020-10-03T12:51:33","slug":"older-people-like-president-trump-are-at-more-risk-from-covid-19-because-of-how-the-immune-system-ages","status":"publish","type":"post","link":"https:\/\/canadianinquirer.net\/v1\/2020\/10\/03\/older-people-like-president-trump-are-at-more-risk-from-covid-19-because-of-how-the-immune-system-ages\/","title":{"rendered":"Older people like President Trump are at more risk from COVID-19 because of how the immune system ages"},"content":{"rendered":"
\"\"<\/a>
FILE: President of the United States Donald Trump speaking at the 2017 Conservative Political Action Conference (CPAC) in National Harbor, Maryland. (Photo<\/a>: Gage Skidmore\/Flickr<\/a>, CC BY-SA 2.0<\/a>)<\/figcaption><\/figure>\n

President Donald Trump\u2019s announcement that he\u2019s tested positive for COVID-19<\/a> is especially concerning because of his age. At 74 years old, Trump is solidly within an age group that\u2019s been hit hard during the coronavirus pandemic.<\/p>\n

People of all ages can get sick from SARS-CoV-2, the virus that causes COVID-19. But the severity of the illness tends to worsen the older the patient is. Through the end of September, 79% of COVID-19 deaths<\/a> in the United States had been in patients over 65. These statistics are broadly similar<\/a> in countries around the world<\/a>.<\/p>\n

What is it that puts older people at increased risk from viruses like SARS-CoV-2? Scientists think it\u2019s primarily due to changes in the human immune system as we age.<\/p>\n

Your body\u2019s tools to fight off virus infections<\/h2>\n

As you go about your life, your body is constantly bombarded by pathogens \u2013 the bacteria, fungi and viruses that can make you sick. A human body is a great place for these organisms to grow and thrive, providing a nice warm environment with plenty of nutrients.<\/p>\n

That\u2019s where your immune system comes in. It\u2019s your body\u2019s defense system against these kinds of invaders. Before you\u2019re even born, your body starts producing specialized B-cells and T-cells \u2013 types of white blood cells that can recognize pathogens and help block their growth.<\/p>\n

During an infection, your B-cells can proliferate and produce antibodies that grab onto pathogens and block their ability to spread within your body. T-cells work by recognizing infected cells and killing them. Together they make up what scientists call your \u201cadaptive\u201d immune system.<\/p>\n

Maybe your physician has checked your white blood cell levels. That\u2019s a measurement of whether you have more B-cells and T-cells in your blood than usual, presumably because they\u2019re fighting infection.<\/p>\n

When you\u2019re very young, you don\u2019t have a lot of these B- or T-cells. It can be a challenge for your body to control infection because it\u2019s simply not used to the job. As you mature, your adaptive immune system learns to recognize pathogens and handle these constant invasions, allowing you to fight off infection quickly and effectively.<\/p>\n

While white blood cells are powerful people-protectors, they\u2019re not enough on their own. Luckily, your immune system has another layer, what\u2019s called your \u201cinnate\u201d immune response<\/a>. Every cell has its own little immune system that allows it to directly respond to pathogens quicker than it takes to mobilize the adaptive response.<\/p>\n

The innate immune response is tuned to pounce on types of molecules that are commonly found on bacteria and viruses but not in human cells. When a cell detects these invader molecules, it triggers production of an antiviral interferon protein. Interferon triggers the infected cell to die, limiting infection.<\/p>\n

Another type of innate immune cell, called a monocyte, acts as a sort of cellular bouncer, getting rid of any infected cells it finds and signaling the adaptive immune response to shift into gear.<\/p>\n

The innate and adaptive immune systems can act together as a fine-tuned machine to detect and clear out pathogens.<\/p>\n

Older immune systems are weaker<\/h2>\n

When a pathogen invades, the difference between illness and health is a race between how fast the pathogen can spread within you and how fast your immune response can react without causing too much collateral damage.<\/p>\n

As people age, their innate and adaptive immune responses change, shifting this balance.<\/p>\n

Monocytes from older individuals<\/a> produce less interferon<\/a> in response to viral infections. They have a harder time killing infected cells and signaling the adaptive immune response to get going.<\/p>\n

Low-grade chronic inflammation in individuals that commonly occurs during aging can also dull the ability of the innate and adaptive immune responses<\/a> to react to pathogens. It\u2019s similar to becoming used to an annoying sound over time.<\/p>\n

As you age, the reduced \u201cattention span\u201d of your innate and adaptive immune responses make it harder for the body to respond to viral infection, giving the virus the upper hand. Viruses can take advantage of your immune system\u2019s slow start and quickly overwhelm you, resulting in serious disease and death.<\/p>\n

Social distancing is vital<\/h2>\n

Everyone, no matter their age, needs to protect themselves from infection, not just to keep themselves healthy but also to help protect the most vulnerable. Given the difficulty older individuals have in controlling viral infection, the best option is for these individuals to avoid becoming infected by viruses in the first place.<\/p>\n

This is where washing hands, avoiding touching your face, self-isolation and social distancing<\/a> all become important, especially for COVID-19<\/a>.<\/p>\n

COVID-19 is caused by a respiratory virus, which can spread via tiny virus-containing droplets. Larger droplets fall to the ground quickly; very small droplets dry up. Mid-range droplets are of most concern because they can float in the air for a few feet<\/a> before drying. These droplets can be inhaled into the lungs.<\/p>\n

Keeping at least 6 feet away from other people helps significantly reduce your chance of being infected by these aerosol droplets<\/a>. But there\u2019s still the possibility for virus to contaminate surfaces<\/a> that infected people have touched or coughed on. Therefore, the best way to protect vulnerable older and immunocompromised people is to stay away from them until there is no longer a risk. By stopping the spread of SARS-CoV-2 throughout the whole population, we help protect those who have a harder time fighting infection.<\/p>\n

This article draws on material from an article originally published<\/a> on March 19, 2020.<\/em>\"The<\/p>\n

Brian Geiss<\/a>, Associate Professor of Microbiology, Immunology & Pathology, Colorado State University<\/a><\/em><\/p>\n

This article is republished from The Conversation<\/a> under a Creative Commons license. Read the original article<\/a>.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

President Donald Trump\u2019s announcement that he\u2019s tested positive for COVID-19 is especially concerning because of his age. At 74 years …<\/p>\n","protected":false},"author":44,"featured_media":231771,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-270727","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","mauthors-brian-geiss-colorado-state-university","mauthors-the-conversation"],"_links":{"self":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/270727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/comments?post=270727"}],"version-history":[{"count":1,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/270727\/revisions"}],"predecessor-version":[{"id":270728,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/270727\/revisions\/270728"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media\/231771"}],"wp:attachment":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media?parent=270727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/categories?post=270727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/tags?post=270727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}