{"id":268255,"date":"2020-09-10T06:04:32","date_gmt":"2020-09-10T10:04:32","guid":{"rendered":"https:\/\/canadianinquirer.net\/v1\/?p=268255"},"modified":"2020-09-10T06:04:32","modified_gmt":"2020-09-10T10:04:32","slug":"5-ways-our-immune-responses-to-covid-vaccines-are-unique","status":"publish","type":"post","link":"https:\/\/canadianinquirer.net\/v1\/2020\/09\/10\/5-ways-our-immune-responses-to-covid-vaccines-are-unique\/","title":{"rendered":"5 ways our immune responses to COVID vaccines are unique"},"content":{"rendered":"<figure id=\"attachment_260477\" aria-describedby=\"caption-attachment-260477\" style=\"width: 1280px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-260477\" src=\"https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280.jpg\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280.jpg 1280w, https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280-300x169.jpg 300w, https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280-768x432.jpg 768w, https:\/\/canadianinquirer.net\/v1\/wp-content\/uploads\/2020\/07\/coronavirus-4972480_1280-1024x576.jpg 1024w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption id=\"caption-attachment-260477\" class=\"wp-caption-text\">We don\u2019t yet know whether reports of immune complications in one or two trial participants have been linked to the COVID-19 vaccine itself, or if they were given the placebo vaccine. (Pixabay photo)<\/figcaption><\/figure>\n<p>The Oxford vaccine trial at the centre of <a href=\"https:\/\/www.statnews.com\/2020\/09\/08\/astrazeneca-covid-19-vaccine-study-put-on-hold-due-to-suspected-adverse-reaction-in-participant-in-the-u-k\/\">safety concerns<\/a> this week highlights the idea that people\u2019s immune systems respond to vaccines differently.<\/p>\n<p>We don\u2019t yet know whether <a href=\"https:\/\/www.statnews.com\/2020\/09\/09\/astrazeneca-covid19-vaccine-trial-hold-patient-report\/\">reports<\/a> of <a href=\"https:\/\/www.abc.net.au\/news\/2020-09-10\/astrazeneca-oxford-covid-19-vaccine-trial-no-final-diagnosis\/12648248\">immune complications<\/a> in one or two trial participants have been linked to the COVID-19 vaccine itself, or if they were given the placebo vaccine.<\/p>\n<p>But it does highlight the importance of <a href=\"https:\/\/www.australianclinicaltrials.gov.au\/what-clinical-trial\/phases-clinical-trials\">phase 3 clinical trials<\/a> in many thousands of people, across continents. These not only tell us whether a vaccine is safe, but also whether it works for people of different ages or with particular health issues.<\/p>\n<p>So what are some of the immune factors that determine whether any of the <a href=\"https:\/\/www.who.int\/publications\/m\/item\/draft-landscape-of-covid-19-candidate-vaccines\">180 or so COVID-19 vaccine candidates<\/a> being developed around the world actually work?<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/halting-the-oxford-vaccine-trial-doesnt-mean-its-not-safe-it-shows-theyre-following-the-right-process-145837\">Halting the Oxford vaccine trial doesn&#8217;t mean it&#8217;s not safe \u2013 it shows they&#8217;re following the right process<\/a><br \/>\n<\/strong><br \/>\n<\/em><\/p>\n<hr \/>\n<h2>Our immune responses are all different<\/h2>\n<p>An effective vaccine should generate long-lasting protective immunity against SARS-CoV-2, the virus that causes COVID-19.<\/p>\n<p>This can be by generating <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.08.13.20173161v1\">antibodies to neutralise<\/a> the virus and likely also by helping the immune system memorise and quickly respond to infection.<\/p>\n<figure><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/-muIoWofsCE?wmode=transparent&amp;start=0\" width=\"440\" height=\"260\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><figcaption><span class=\"caption\">How vaccines work with your immune system to protect against disease.<\/span><\/figcaption><\/figure>\n<p>We know, from developing vaccines against other viruses, that people\u2019s immune response to a vaccine can vary. There\u2019s every reason to believe this will also be the case for a COVID-19 vaccine.<\/p>\n<h2>1. Vaccine type and how it\u2019s delivered<\/h2>\n<p>Many COVID-19 vaccine candidates contain parts of the SARS-CoV-2 <a href=\"https:\/\/theconversation.com\/revealed-the-protein-spike-that-lets-the-2019-ncov-coronavirus-pierce-and-invade-human-cells-132183\">spike protein<\/a> to stimulate protective immunity. However, there are many different ways of delivering these proteins to the body, and some may be more effective than others at stimulating your immune system.<\/p>\n<p>For example, the <a href=\"https:\/\/theconversation.com\/oxford-immunologist-on-coronavirus-vaccine-our-early-results-look-highly-promising-141558\">Oxford vaccine<\/a> combines the spike protein with another virus to mimic the actions of SARS-CoV-2.<\/p>\n<p>Meanwhile, the candidate developed by the <a href=\"https:\/\/theconversation.com\/putting-our-money-on-two-covid-vaccines-is-better-than-one-why-australias-latest-vaccine-deal-makes-sense-145693\">University of Queensland<\/a> contains the spike protein packaged with another compound (an adjuvant) to stimulate the immune system.<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/oxford-scientists-these-are-final-steps-were-taking-to-get-our-coronavirus-vaccine-approved-144623\">Oxford scientists: these are final steps we&#8217;re taking to get our coronavirus vaccine approved<\/a><br \/>\n<\/strong><br \/>\n<\/em><\/p>\n<hr \/>\n<p>Some people will <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)31604-4\/fulltext\">likely need<\/a> a follow-up booster shot to ensure longer-lasting immunity.<\/p>\n<p>We may also see some vaccines <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.08.026\">delivered as a nasal spray<\/a>. This may elicit a more effective immune response to COVID-19 in the <a href=\"https:\/\/medlineplus.gov\/ency\/imagepages\/19378.htm\">upper respiratory tract<\/a>, including the nostrils, mouth and throat.<\/p>\n<h2>2. Our previous infections<\/h2>\n<p>Previous infections may prime our immune system to respond differently to vaccination.<\/p>\n<p>For instance, the SARS-CoV-2 virus belongs to a large family of human coronaviruses, <a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiaa185\">four of which<\/a> are responsible for common colds.<\/p>\n<p>Being exposed to these cold-causing coronaviruses, and <a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/08\/04\/science.abd3871\">developing immune memory cells<\/a> against them, may mean a stronger or quicker response to a COVID-19 vaccine.<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/exposure-to-common-colds-might-give-some-people-a-head-start-in-fighting-covid-19-143455\">Exposure to common colds might give some people a head start in fighting COVID-19<\/a><br \/>\n<\/strong><br \/>\n<\/em><\/p>\n<hr \/>\n<p>Some people have poor protective immune responses to COVID-19 vaccine candidates. These people may have <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)31605-6\/fulltext\">existing immunity<\/a> to the adenovirus used in some vaccines to deliver the SARS-CoV-2 spike protein.<\/p>\n<p>In other words, their body mounts an immune response to the wrong part of the vaccine (the delivery mechanism) and not so much to the characteristic part of the virus (the spike protein).<\/p>\n<h2>3. Our genetics<\/h2>\n<p>Our genes play a large part in <a href=\"https:\/\/www.cell.com\/trends\/immunology\/pdf\/S1471-4906(14)00057-X.pdf\">regulating<\/a> our immune system.<\/p>\n<p>Researchers have already seen <a href=\"https:\/\/www.jimmunol.org\/content\/204\/1_Supplement\/245.27.abstract\">sex differences<\/a>, which are partly governed by genes, in the immune response to the <a href=\"https:\/\/www.researchgate.net\/publication\/296850238_Sex_Differences_in_Influenza_Virus_Infection_Vaccination_and_Therapies\">flu vaccine<\/a>. They have also seen <a href=\"https:\/\/www.nature.com\/articles\/s41577-020-0378-2\">sex differences<\/a> in the immune response to COVID-19.<\/p>\n<p>So larger clinical trials should help us understand whether men and women respond differently to a COVID-19 vaccine.<\/p>\n<p>People with inherited immune deficiencies may <a href=\"https:\/\/www.allergy.org.au\/patients\/immunodeficiencies\/covid-19-and-immunodeficiency\">also be unable<\/a> to generate protective immunity in response to vaccination.<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/what-does-it-mean-to-be-immunocompromised-and-why-does-this-increase-your-risk-of-coronavirus-135200\">What does it mean to be immunocompromised? And why does this increase your risk of coronavirus?<\/a><br \/>\n<\/strong><br \/>\n<\/em><\/p>\n<hr \/>\n<h2>4. Our age<\/h2>\n<p>The composition of our immune system changes throughout the course of our lives, and this affects our ability to mount a protective immune response.<\/p>\n<p>Infants\u2019 and children\u2019s immune systems are still developing. So their immune response <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.09.016\">may be different<\/a> to adults\u2019.<\/p>\n<p>Some COVID-19 vaccines may be more effective for children, or recommended for them, as we see already with the <a href=\"https:\/\/www.health.gov.au\/health-topics\/immunisation\/immunisation-services\/flu-influenza-immunisation-service-0\">flu vaccine<\/a>.<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/putting-our-money-on-two-covid-vaccines-is-better-than-one-why-australias-latest-vaccine-deal-makes-sense-145693\">Putting our money on two COVID vaccines is better than one: why Australia&#8217;s latest vaccine deal makes sense<\/a><br \/>\n<\/strong><br \/>\n<\/em><\/p>\n<hr \/>\n<p>As we get older, changes in our immune system mean we cannot efficiently maintain long-lasting protective immunity; we are less able to make new antibodies in response to infection.<\/p>\n<p>We already know older people are less likely to mount a protective immune response with the <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1521661617308136\">flu vaccine<\/a>.<\/p>\n<p>So we need the data from large trials to verify whether COVID-19 vaccines work in children and elderly people.<\/p>\n<h2>5. Lifestyle factors<\/h2>\n<p>Diet, exercise, stress and whether we smoke <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6431125\/\">influence our immune response<\/a> to vaccination. So we can look after our immune system with a healthy lifestyle where possible.<\/p>\n<p>There is also an <a href=\"https:\/\/science.sciencemag.org\/content\/366\/6469\/1074\">emerging hypothesis<\/a> that our gut microbes may influence our immune response to vaccination. But more research is needed to confirm this could occur during COVID-19 vaccination.<\/p>\n<hr \/>\n<p><em><br \/>\n<strong><br \/>\nRead more:<br \/>\n<a href=\"https:\/\/theconversation.com\/gut-instinct-how-the-way-youre-born-and-fed-affect-your-immune-system-65104\">Gut instinct: how the way you&#8217;re born and fed affect your immune system<\/a><br \/>\n<\/strong><br \/>\n<\/em><br \/>\n<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img loading=\"lazy\" decoding=\"async\" style=\"border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;\" src=\"https:\/\/counter.theconversation.com\/content\/145248\/count.gif?distributor=republish-lightbox-basic\" alt=\"The Conversation\" width=\"1\" height=\"1\" \/><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n<hr \/>\n<p><a href=\"https:\/\/theconversation.com\/profiles\/paul-gill-1145809\">Paul Gill<\/a>, Post-doctoral Researcher (Gastroenterology and Immunology), <em><a href=\"https:\/\/theconversation.com\/institutions\/monash-university-1065\">Monash University<\/a><\/em> and <a href=\"https:\/\/theconversation.com\/profiles\/menno-van-zelm-1150452\">Menno van Zelm<\/a>, Associate Professor, Immunology, <em><a href=\"https:\/\/theconversation.com\/institutions\/monash-university-1065\">Monash University<\/a><\/em><\/p>\n<p>This article is republished from <a href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a href=\"https:\/\/theconversation.com\/5-ways-our-immune-responses-to-covid-vaccines-are-unique-145248\">original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Oxford vaccine trial at the centre of safety concerns this week highlights the idea that people\u2019s immune systems respond &hellip;<\/p>\n","protected":false},"author":33,"featured_media":260477,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-268255","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","mauthors-paul-gill-monash-university","mauthors-menno-van-zelm-monash-university","mauthors-the-conversation"],"_links":{"self":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/268255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/comments?post=268255"}],"version-history":[{"count":1,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/268255\/revisions"}],"predecessor-version":[{"id":268256,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/posts\/268255\/revisions\/268256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media\/260477"}],"wp:attachment":[{"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/media?parent=268255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/categories?post=268255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/canadianinquirer.net\/v1\/wp-json\/wp\/v2\/tags?post=268255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}